• Bioinstrumentation
• Biomarker Detection
  • NIAD-4
• Industrial Monitoring
• Radars

Overview

Amyloid-β binding fluorophore for molecular imaging Dramatic red fluorescence when bound to amyloid-β

Alzheimer's disease is the most common form of dementia and affects an estimated 4.5 million Americans. It is hypothesized that the development of the disease corresponds to the spread of amyloid-β through the brain. Presently, the only reliable diagnosis of Alzheimer's disease is through post-mortem examination to determine the presence of amyloid-β. The development of safe and effective techniques to track the spread of amyloid-β in living subjects could radically change the diagnosis and treatment path of this devastating disease.

NIAD-4 is a small fluorophore that crosses the blood-brain barrier and upon binding to amyloid-β plaques emits strong red (625 nm) fluorescence. Paired with fluorescence imaging techniques, NIAD-4 makes possible chronic imaging studies to study the effect of amyloid-β on brain function.

• NIAD-4 Flyer