NIAD-4™
Amyloid-β Binding Fluorophore for Molecular Imaging

References

  1. Hardy, J. and D.J. Selkoe. 2002.
    The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
    Science. 297:353-356.
  2. Nesterov, E.E., J. Skoch, B.T. Hyman, W.E. Klunk, B.J. Bacskai and T.M. Swager 2005.
    In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
    Angewandte Chemie, International Edition. 44(34):5452-5456.
  3. Bacskai, B.J., G.A Hickey, J. Skoch, S.T. Kajdasz, Y. Wang, G-F. Huang, C.A. Mathis, W.E. Klunk, B.T. Hyman. 2003.
    Four-dimensional multiphoton imaging of brain entry, amyloid binding and clearance of an amyloid-ß ligand in transgenic mice.
    Proc. Natl. Acad. Sci. USA. 100(21):12462-12467.
  4. Skoch, J., G.A. Hickey, S.T. Kajdasz, B.T. Hyman and B.J. Bacskai. 2005.
    In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy.
    Methods Mol. Biol. 299:349-363.
  5. Far Red Fluorophores