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  • Pittsburgh Facilities and Labs
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Pittsburgh Facilities & Labs

ICx Agentase currently houses its R&D and small-scale manufacturing efforts at a centralized location. Our primary research facilities and main offices are located at 2240 William Pitt Way, within the University of Pittsburgh Applied Research Center (UPARC). 

We have roughly 9500 square feet of modern research and engineering space equipped with chemical (external exhaust) fume hoods. Laboratory analytical equipment on-site consists of spectrophotometers, an auto-sampling gas chromatograph (FID, NPD dual detectors), ion meters and pH sensors.

ICx Agentase owns a solid-phase Minolta CM-500d spectrophotometer (colorimeter). The colorimeter will be used to conduct quantitative analyses of sensor color changes and reaction rates. We have an HP 1050 HPLC system with variable wavelength detector including pump, auto sampler, Chemstation data system and accompanying hardware. This device is used to purify enzyme preparations and in qualitative analysis of enzyme chemical modification.

ICx also has access to a Matrix Laser Desorption Ionization Time-of-Flight (MALDI-TOF) Mass Spectrometer. This instrument is ideal for quantifying degrees of enzyme modification and enzyme purity.

We have a New Brunswick 5000 BioFlo Fermenter for bacterial fermentation and protein production. All necessary support equipment and materials such as balances, glassware, computers, and graphics software are also available.

ICx is equipped to synthesize enzyme-polyurethane polymers (sponges and fabrics) via semi-batch processes at our facilities in Pittsburgh within our production facility. The facility consists of polymer reactors, cutting equipment, and a series of dies and presses to produce components having a variety of shapes and sizes. Existing production capability is sufficient to produce several thousand polymer sensors per week.

We have direct access to additional large scale processing equipment at the facilities of one of our collaborators through a contract manufacturing relationship. We have made use of these production capabilities in both pilot-plant scale-up studies as well as a large-scale commercial run of enzyme-containing polymer. As product demands increase, the procurement and installation of larger-scale equipment is possible within our facilities.